Oklahoma State University
Nutritional Sciences
Edralin A. Lucas

Edralin Lucas

Associate Professor


Area: Nutritional Sciences and analytical chemistry

422 Human Sciences
Stillwater OK 74078
 
Phone: 405-744-3132
Fax: 405-744-1357
edralin.a.lucas@okstate.edu

  • Profile
  • Publications
  • Research

Educational Background:

Degree Institution Area of Study
Ph.D. Oklahoma State University Analytical Chemistry
B.S. University of Santo Tomas Chemistry

Courses Taught:

Careers in Nutritional Sciences NSCI  2111
Principles of Nutrition NSCI  2114
Advanced Human Nutrition NSCI  5463
Experimental Methods in Nutritional Sciences NSCI  5743
Macronutrition NSCI  6023

Service:

  • 2003, Ad hoc reviewer, USDA National Research Initiative Competitive Grants; Improving Nutrition for Optimal Health. Reviewer
  • 2004, Ad hoc reviewer, USDA National Research Initiative Competitive Grants; Improving Nutrition for Optimal Health.
  • 2005, Ad hoc panel, NP 107 Human Nutrition Ad Hoc Panel.

Awards & Recognition:

  • Marguerite Scruggs Award for Early Career Meritorious Research, April 2008
  • Nominated for COHS Outstanding Graduate Faculty Mentor Award, 2006, 2007
  • Summer Institute on Aging Research Awardee, National Institute on Aging, NIH, 2006

Professional Memberships:

  • American Society of Nutritional Sciences
  • Sigma Xi Honor Society
  • American Society of Bone and Mineral Research
  • American Chemical Society

Research Statement:

My research group investigates the potential for naturally occurring compounds in foods, their isolated components, or analogues that could be incorporated into the diet and prevent chronic diseases particularly cardiovascular disease, obesity, diabetes, osteoporosis, and cancer. Currently, we have two clinical studies that will investigate the effect of freeze-dried mango on body composition in obese individuals and on blood sugar in pre-diabetics. We also have another study that will investigate the effects of mango on skeletal health using an animal model. I teach our core graduate class, Macronutrients, in the fall and our basic nutrition class, Principles of Human Nutrition, in the spring. I am also working as a co-editor of a book entitled Arachidonic Acid: Dietary Sources and General Functions and writing a book chapter entitled Flaxseed and effects on lipids in an animal model of menopause.

Research Areas:

  • Obesity
  • Dyslipidemia
  • Nutritional Biochemistry
  • clinical chemistry
  • analytical methods
  • cardiovascular and skeletal health
  • Functional food

Grants:

  • Kuvibidila S, Lucas E, Clarke SL, Smith BJ and Lightfoot S. Effect of mushrooms on endothelin-1 secretion and cancer. Funding agency: Oklahoma Center for the Advancement of Science and Technology; duration: 2009-2011.
  • Clarke SL, Lucas EA, and Smith BJ. Common mechanisms controlling the response to iron and oxygen availability. Funding agency: USDA-NRI; duration: 2008-2010.
  • Lucas EA, Perkins-Veazie P, Smith BJ, Clarke SL, Kubividila SK, Lightfoot SA. Effects of mango on bone parameters in high fat diet-induced obesity. Funding agency: Mango Board; amount: $25,016; duration: October 2008- July 2009.
  • Lucas EA, Perkins-Veazie P, Smith BJ, Lightfoot SA. Mango modulates glucose and lipid parameters in high fat diet-induced obesity. Funding agency: Mango Board; amount: $49,981.74; duration: September 2007- December 2008.
  • Lucas EA, Smith BJ, Hill M, Lightfoot SA, Payton M. Momordica charantia modulates glucose and lipid parameters in high fat diet-induced obesity. Funding agency: USDA-NRI; amount: $306,740; duration: 2007-2009.
  • Lucas EA, Stafne ET, Parker SP, Brown B. Evaluation of the anti-inflammatory properties of juice from grape varieties grown in Oklahoma. Funding agency: Oklahoma Agriculture Experiment Station; amount: $81,798; duration: 2007-2009

Publications:

  • Evans, S. F., Meister, M., Mahmood, M., Eldoumi, H., Peterson, S., Perkins-Veazie, P., & Lucas, E. A. (2014). Mango supplementation improves blood glucose in obese individuals. Nutrition and Metabolic Insights, 7, 77–84.
  • Basu, A., Lucas, E.A., Chen J, & Lyons TJ (2013). Protective Effects of Green Tea in Metabolic Syndrome. Tea in Health and Disease Prevention, (Editor: Victor Preedy). Academic Press; Copyright 2013 Elsevier Inc. (ISBN: 9780123849373)
  • Davis, M.R., Hester, K.K., Lucas, E.A., Shawron, K.M., Smith, B.J., & Clarke, S.L. (2012). Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet. Nutrition and Metabolism, 9(1): 95
  • Davis, M.R., Smith, B.J., Lucas, E.A., & Clarke, S.L. (2012). Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes Nutrition, 7(3):415-25.
  • Lucas, E.A., Brown A, Li W, Peterson SK, Wang Y, Perkins-Veazie P, Clarke, S.L., & Smith, B.J. (2012). Mango modulates blood glucose similar to rosiglitazone without compromising bone parameters in mice fed high fat diet. J Pharm and Nutrition Sciences, 2(2): 115-126.
  • Rendina, E., Lim YF, Marlow D, Wang Y, Clarke, S.L., Kuvibidila, S., Lucas, E.A., & Smith, B.J. (2012). Dietary supplementation with dried plum prevents ovariectomy-induced bone loss in C57BL/6 mice and modulates the immune response. Journal of Nutrition, 23(1):60-8.
  • Chandra Christopher L, Lucas, E.A., Clarke, S.L., Smith, B.J., & Kuvibidila, S. (2011). White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis in dilute brown non-agouti mice. Journal of Nutrition, 141(1):131-136.
  • Davis MR, Shawron KM, Rendina E, Lucas, E.A., Smith, B.J., & Clarke, S.L. (2011). Hypoxia Inducible Factor 2-alpha is Translationally Repressed in Response to a Dietary Iron Deficiency in Sprague-Dawley Rats. Journal of Nutrition, 141(9): Epub 2011 Jul 13. PMID: 21753061
  • Lucas, E.A., Li W, Peterson SK, Brown A, Kuvibidila S, Perkins-Veazie P, Clarke, S.L., & Smith, B.J. (2011). Mango modulates body fat and plasma glucose and lipids in mice fed high fat diet. British Journal of Nutrition, 106(10):1495-505.
  • Lucas, E.A., Mahajan SS, Soung DY, Lightfoot SA, Smith, B.J., & Arjmandi BH (2011). Flaxseed but not flaxseed oil prevented the rise in serum cholesterol due to ovariectomy in the golden Syrian hamsters. J Med Food, 14(3):261-7.
  • Peterson SK, Lucas, E.A., Traore D, Christopher LC, French C, Clarke, S.L., Lightfoot SA, Smith, B.J., & Kuvibidila, S. (2011). Effects of Portabella mushrooms on collagen-induced arthritis, inflammatory cytokines, and body composition in dilute brown non-agouti (DBA1) mice. Functional Foods in Health and Disease, 1(9):279-296.
  • Lucas, E.A., Dumancas GG, Smith, B.J., Clarke, S.L., & Arjmandi BH (2009). Health benefits of bitter melon (Momordica charantia). Johnson CD, Lucas, E.A., Hooshmand S, Campbell S, Akhter MP, Arjmandi BH. Addition of fructooligosaccharides and dried pum to soy-based diets reverses bone loss in the ovariectomized rat. Evid Based Complement Alternat Med. 2008 Jul 30.
  • Lawrance, C.C., Lucas, E.A., Clarke, S.L., Smith, B.J., & Kuvibidila (2009). Differential effects of isofluorane and CO2 inhalation on plasma levels of inflammatory markers associated with collagen-induced arthritis in DBA mice. Int. J. Immunopharmacol, 9(7-8):807-9.
  • Patade A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy B. P., & Arjmandi, B. H. (2008). Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. J Women’s Health, 17(3), 355-366.
  • Bu, S.Y., Lerner, M., Stoecker, B.J., Boldrin, E., Brackett, D.J., Lucas, E.A., & Smith, B.J. (2008). Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATcl and inflammatory mediators. Calcified Tissue International, 82(6):475-88.
  • Hooshmand S, Soung DY, Lucas, E.A., Madihally SV, Levenson C, & Arjmandi BH (2007). Genistein reduces the production of proinflammatory molecules in human chondrocytes. J Nutr Bioch, 18(9):609-14.
  • Basu, A, & Lucas, E.A.   (2007). Mechanisms and effects of green tea on cardiovascular health. Nutrition Reviews, 65: 361-75.
  • Bu SY, Lucas, E.A., Franklin M, Marlow D, Brackett DJ, Boldrin EA, Devareddy L, Arjmandi BH, & Smith, B.J. (2007). Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporosis International, 18(7):931-42.
  • Bu, S.Y., Lucas, E.A., Franklin, M., Marlow, D., Brackett, D.J., Boldrin, E.A., Devareddy, L., Arjmandi, B.H., & Smith, B.J. (2007). Restoration of bone mass and microarchitecture by dietary dried plum is comparable to PTH in osteopenic orchidectomized rats. Osteoporosis International, 18(7):931-42.
  • Devareddy L, Khalil DA, Smith, B.J., Lucas, E.A., Soung DY, Marlow DD, & Arjmandi BH (2006). Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone, 38(5):686-93.
  • Devareddy, L., Soung, D.Y., Smith, B.J., Lucas, E.A., Khalil, D.A., Marlow, D.D., & Arjmandi, B.H. (2006). Soy moderately improves bone mass and microstructural properties in an ovariectomized rat model of osteoporosis Bone, 38(5):686-93.
  • Franklin, M., Bu, S.Y., Lerner, M.R., Lancaster, E.A., Bellmer, D., Marlow, D., Arjmandi, B.H., Brackett, D.J., Lucas, E.A., & Smith, B.J. (2006). Dried plum down-regulates RANKL and OPG and prevents bone loss in a male model of osteoporosis. Bone, 39(6):1331-42.
  • Lucas, E.A., Chen, T., Chai, S., Wei, C.I., Tripathi, Y.B., Daggy, B.P., Hwang, D., & Arjmandi, B.H. (2006). Effect of vitamin E on lipid parameters in ovariectomized rats. Journal of Medicinal Food, 9 (1):77-83.
  • Smith, B.J., Lerner, M.R., Bu, S.Y., Lucas, E.A., Hanas, J.S., Lightfoo, S.A., Bronze, M.S., Postier, R.G., & Brackett, D.J. (2006). Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. Bone, 38(3):378-86.
  • Soung DY, Devareddy L, Khalil DA, Hooshmand S, Patade A, Lucas, E.A., & Arjmandi BH (2006). Soy affects trabecular microarchitecture and favorably alters select bone-specific gene expressions in a male rat model of osteoporosis. Calcified Tissue International, 78(6):385-91.
  • Soung DY, Patade A, Khalil DA, Lucas, E.A., Devareddy L, Greaves KA, & Arjmandi BH (2006). Soy protein supplementation does not cause lymphocytopenia in postmenopausal women. Nutrition Journal, 11:12
  • Arjmandi, B.H., Lucas, E.A., Smith, B.J., Khalil, D.A., McDonald, J., Devareddy, L., Arquitt, A.B., Payton, M.E., & Mason, C. (2005). One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women, Nutrition Journal, 4(1): 8.
  • Khalil, D.A., Lucas, E.A., Smith, B.J., Soung, D.Y., Devareddy, L., Juma, S., Akhter, M.P., Recker, R., & Arjmandi, B.H. (2005). Soy isoflavones ameliorate bone loss in aged orchidectomized male rats. Calcified Tissue International, 76(1):56-62.
  • Smith, B.J., Lucas, E.A., Turner, R.T., Evans, G.L., Lerner, M.R., Brackett, B.J., Stoecker, B.J., & Arjmandi, B.H. (2005). Vitamin E provides protection for bone in mature hind limb unloaded male rats. Calcified Tissue International, 76(4):272-279
  • Arjmandi, B.H., Khalil, D.A., Lucas, E.A., Smith, B.J., Sinichi, N., Hodges, S.B., Juma, S., Munson, M.E., Payton, M.E., Tivis, R.D., & Svanborg, A. (2004). Soy protein may alleviate osteoarthritis symptoms, Phytomedicine, 11(7-8): 567-75.
  • Lucas, E.A., Hammond, L.J., Mocanu, V., Arquitt, A.B., Trolinger, A., Khalil, D.A., Smith, B.J., Soung, D.Y., Daggy, B.P., & Arjmandi, B.H. (2004). Daily consumption of dried plum by postmenopausal women does not cause undesirable changes in bowel function, Journal of Applied Research, 4: 37-43.
  • Lucas, E.A., Lightfoot, S.A., Hammond, L.J., Devareddy, L., Khalil, D.A., Daggy, B.P., Smith, B.J., Westcott, N., Mocanu, V., & Arjmandi, B.H. (2004). Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters. Atherosclerosis, 173, 223-229.
  • Rhee, Y.S., Burnham, K., Stoecker, B.J., & Lucas, E. (2004). Effects of chromium and copper depletion on lymphocyte reactivity to mitogens in diabetes-prone BHE/cdb rats. Nutrition, 20(3), 274-279.
  • Soung, D.Y., Khalil, D.A., Arquitt, A.B., Smith, B.J., Hammond, L.J., Droke, E.A., Lucas, E.A., Devareddy, L., & Arjmandi, B.H. (2004). Soy isoflavones prevent the ovarian hormone deficiency-associated rise in leukocytes in rats. Phytomedicine, 11, 303-308.
  • Arjmandi, B.H., Khalil, D.A., Smith, B.J., Lucas, E., Juma, S., Payton, M.E., & Wild, R.D. (2003). Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy as evidenced by reducing bone resportion and urinary calcium excretion. Journal of Clinical Endocrinology and Metabolism, 88(3), 1048-1054.
  • Lucas, E.A., Lightfoot, S.A., Hammond, L.J., Devareddy, L., Khalil, D.A., Daggy, B.P., Soung, D.Y., & Arjmandi, B.H. (2003). Soy isoflavones prevent ovariectomy-induced hypercholesterolemia and atherosclerotic lesions in Golden Syrian hamsters. Menopause: The Journal of the North American Menopause Society, 10(4), 314-320.
  • Toure, F., Lucas, E., & Stoecker, B. (2003). Fish and shrimp added bioavailable iodine to cassava and millet-based diets. Ecology of Food & Nutrition, 42, 223-239.
  • Arjmandi, B.H., Khalil, D.A., Lucas, E.A., Georgis, A., Stoecker, B.J., Hardin, C., Payton, M.E., & Wild, R.A. (2002). Dried plums improve indices of bone formation in postmenopausal women. Journal of Women's Health and Gender-Based Medicine, 11, 61-68.
  • Khalil, D.A., Lucas, E.A., Smith, B.J., Payton, M.E., & Arjmandi, B.H. (2002). Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. Journal of Nutrition, 132(9), 2605-2608.
  • Lucas, E.A., Wild RD, Hammond LJ, Khalil DA, Juma S, Daggy BP, Stoecker, B.J., & Arjmandi BH (2002). Flaxseed improves lipid profile without altering biomarkers of bone metabolism in postmenopausal women. J Clin Endocrinol Metab, 87(4):1527-1532.
  • Smith, B.J., King, J.B., Lucas, E.A., Akhter, M., Arjmandi, B.H., & Stoecker, B.J. (2002). Skeletal unloading and dietary copper depletion are detrimental to bone quality of mature rats. Journal of Nutrition, 132(2), 190-196.
  • Arjmandi BH, Lucas, E.A., Juma S, Soliman A, Stoecker, B.J., Khalil DA, Smith, B.J., & Wang C (2001). Prune pevents ovariectomy-induced bone loss in rats. Journal of American Nutraceutical Association, 4(1):50-56.
  • Arjmandi, B.H., Lucas, E.A., Juma, S., Soliman, A., Stoecker, B.J., Khalil, D.A., Smith, B.J., & Wang, C. (2001). Dried plums prevent ovariectomy-induced bone loss in rats. Journal of the American Nutraceutical Association, 4(1), 50-56.
  • Lucas, E.A., Khalil, D.A., Daggy, B.P., & Arjmandi, B.H. (2001). Ethanol-extractred soy protein isolate does not modulate serum cholesterol in Golden Syrian hamsters: A model of postmenopausal hypercholesterolemia. Journal of Nutrition, 131, 211-214.
  • Lucas, E.A., Juma S, Stoecker, B.J., & Arjmandi BH (2000). Prune dose-dependently suppresses ovariectomy-induced hypercholesterolemia in rats. J Nutr Biochem, 11:255-259.
  • Lucas, E.A., Juma, S., Stoecker, B.J., & Arjmandi, B.H. (2000). Prune dose-dependently suppresses ovariectomy-induced hypercholesterolemia in rats. The Journal of Nutritional Biochemistry, 11:255-259.
  • Arjmandi BH, Juma S, Lucas, E.A., Wei LL, Venkatesh S,, & Khan DA (1998). Effects of flaxseed supplementation on bone metabolism in postmenopausal women. Proc Flax Inst N Am, 57:65-74.
  • Arjmandi, B.H., Juma, S., Lucas, E.A., Wei, L. L., Venkatesh, S., & Khan, D.A. (1998). Flaxseed supplementation positively influence bone metabolism in postmenopausal women. Journal of the American Nutraceutical Association, 1, 27-32.
  • Engle, A.R., Lucas, E.A., & Purdie, N. (1994). Determination of enantiomers in ephedrine mixtures by polarimetry. Journal of Pharmaceutical Science, 83, 1310-1314.
  • Purdie, N., Lucas, E.A., & Tally, M.B. (1992). Direct measure of total cholesterol and its distribution among major serum lipoproteins. Clinical Chemistry, 38, 1645-1646.