Oklahoma State University
Nutritional Sciences
Brenda J. Jane Smith

Brenda J. Smith

Professor and John and Sue Taylor Professorship

420 Human Sciences
Stillwater OK 74078
 
Phone: 405-744-3866
Fax: 405-744-1357
bjsmith@okstate.edu

  • Profile
  • Publications
  • Research

Educational Background:

Degree Institution Area of Study
Post-doc Oklahoma State University, Stillwater, OK Nutrition & Bone Metabolism
Ph.D. Oklahoma State University, Stillwater, OK Human Nutrition
M.S. University of Texas at Tyler, Tyler, TX Clinical Exercise Physiology
B.S. Oklahoma Baptist University, Shawnee, OK Exercise Science

Course(s) Taught:

Careers in Nutrition NSCI  2111
Principles of Human Nutrition NSCI  2114
Nutrition & Health Issues NSCI  4023
Nutrition for Exercise and Sport NSCI  4133
Advanced Nutrition and Health Issues NSCI  5023
Research Developments in Nutritional Sciences NSCI  5123
Nutrition and Aging NSCI  5393
Seminar in Nutritional Sciences NSCI  5961
Advanced Studies in Nutritional Sciences NSCI  6961

Service:

  • Basic Science Counselor, Society of Shock, Injury, Inflammation, and Sepsis (2008-2012)
  • Co-Chair of Mentoring Committee, Society of Shock, Injury, Inflammation & Sepsis
  • Editorial Board Member, PLoS One

Awards & Recognition:

  • Oklahoma State University Regent’s Distinguished Research Award, 2009
  • President’s Service Award, Outstanding Advisor Award; Oklahoma State University, 2004
  • Outstanding Graduate Student Mentor Award, College of Human Environmental Sciences; Oklahoma State University, 2004

Professional Memberships:

  • American Society of Bone and Mineral Research
  • American Society for Nutritional Sciences
  • North American Society of Shock Injury, Inflammation and Sepsis
  • American Dietetic Association
  • ADA Sports, Cardiovascular, and Wellness Dietetic Practice Group
  • ADA Research Dietetic Practice Group
  • National Strength and Conditioning Association

Research Statement:

My research interest has focused on factors that contribute to osteoporosis and the osteoprotective effects of the bioactive components in plant-based foods. This work has progressed along two major lines of scientific investigation. First, we have studied how low grade inflammation contributes to systemic skeletal deterioration and the extent to which these alterations share similarities with those observed in aging and type II diabetes. These laboratory-based studies have provided the scientific foundation for clinical trials such as the ongoing study designed to examine the influence of inflammation, body composition and type II diabetes on osteoporosis risk in Native American women. Second, our work has focused on the development of nutritional treatment strategies through our efforts to identify the bioactive compounds found in dried plums and the unique mechanisms by which these compounds reverse bone loss. The overarching goal of this research program is to utilize a translational research approach to better understand how inflammation and oxidative stress negatively impact bone metabolism; and to use this information to develop effective osteoporosis treatment strategies. All of these research endeavors impact my instructional efforts in the area of nutrition, chronic disease and aging.

Research Areas:

  • Effects of phytochemicals and exercise on bone health
  • Inflammation, nutrition and aging
  • Role of immune and antioxidant systems on bone biology

Grants:

  • Smith, B.J., Lucas, E.A., Lightfoot, S., Cullen, D. Funding Source: United States Department of Agriculture. How does dried plum reverse bone loss? Duration: 2006 - 2011)
  • Lucas EA, Smith BJ, Clarke SL, Stoecker BJ, Perkins-Veazie P, Lightfoot SA. Funding Source: National Mango Board. Mango Improves Bone Parameters in Ovariectomized Mice, a Model of Osteoporosis in Postmenopausal Women. Duration: 2011 - 2013.
  • Lucas, E.A., Smith B.J., Peyton, M.,Lightfoot, S., Hill, M. R. Funding Source: United States Department of Agriculture. Momordica Charantia Modulates Glucose and Lipid Parameters in High Fat Diet-induced Obesity. Duration: 2007 - 2011.
  • Smith BJ. Funding Source: Vice President of Research and College of Human Environmental Sciences. Osteoporosis Risk in Oklahoma Native American Women (continuation), Duration: 2010 - 2011.
  • Smith BJ, Lucas EA, Clarke SL and Tim Griffin. Funding Source: Oklahoma Agricultural Experiment Station, The Role of Exercise in the Prevention of Bone Metabolic Changes Associated with Diet-induced Obesity, Duration: 2010 - 2012.
  • Smith BJ & Lucas EA. Funding Source: OSU Technology and Business Program. Identification of the Bioactive Components in a Dried Plum for Future Commercialization. Duration: 2010 - 2012.
  • Smith BJ and Halloran B. Funding Source: California Dried Plum Board. Dried Plum’s Mechanism of Action in the Prevention of Age-related Osteoporosis. Duration: 2010 - 2012.
  • Smith BJ, Lucas E, Clarke SL and Gimble J. Funding Source: Oklahoma Center for the Advancement of Science & Technology. Dysregulation of Bone Metabolism with Type 2 Diabetes. Duration: 2010 – 2013.
  • Stoecker BJ and Smith BJ. Funding Source: Oklahoma Center for the Advancement of Science and Technology. Selenium’s Effects on Chronic Inflammation and Bone Quality. Duration: 2008 - 2011.
  • Ley T, Apblett A., Bulut R, Cruse A, Hanan JC, Smay JE, Veenstra JN, Blum FD, Gregg J, Ownby C, Smith BJ. Funding Source: Oklahoma Transportation Commission. Procurement of Novel Microanalysis Equipment for Constructions Materials. Duration: 2010 - 2011.
  • Hildebrand R and Smith BJ. Funding Source: Mid-America Athletic Trainers’ Association. The Effects of Vitamin D Supplementation on Strength and Power in Collegiate Students and Division I Student-Athletes. Duration: 2010 - 2011.
  • Dionne C, Ertl W, Smith BJ, Day J, Cummuri S, and Skaggs J. Funding Source: Oklahoma Center for the Advancement of Science and Technology. Residual Limb Measures During Performance of Biomechanical Work Related Activities in Adults with Trans-tibial Amputation Secondary to a Traumatic Event. Duration: 2011 - 2014.
  • Dionne C, Ertl W, Smith BJ, Day J, Cummuri S, and Skaggs J. Funding Source: University of Oklahoma Health Sciences Center VP for Research Seed Grant. Residual Limb Measures During Performance of Biomechanical Work Related Activities in Adults with Trans-tibial Amputation Secondary to a Traumatic Event. Duration: 2011 - 2013.

Publications:

  • Meister M, Smith, B.J., Arjmandi BH, & Lucas, E.A. (in press). Effects of Flaxseed on Cardiovascular Disease Risk Factors During Menopause. In RR Watson and V Preedy (Eds.), Handbook of Nutrition and Diet in Menopause. Handbook of Nutrition and Diet in Menopause, edited by RR Watson and V Preedy (King’s College, London).
  • Smith, B.J., Rendina B, & Lucas, E.A. (in press). Bioactive Foods, Nutrients and Plant Extracts in Health. In RR Watson and VR Preedy (Eds.), Bioactive Foods in Promoting Health: Probiotics and Prebiotics. Elsevier Press.
  • Davis, M.R., Hester, K.K., Lucas, E.A., Shawron, K.M., Smith, B.J., & Clarke, S.L. (2012). Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet. Nutrition and Metabolism, 9(1): 95
  • Davis, M.R., Smith, B.J., Lucas, E.A., & Clarke, S.L. (2012). Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes Nutrition, 7(3):415-25.
  • Lucas, E.A., Brown A, Li W, Peterson SK, Wang Y, Perkins-Veazie P, Clarke, S.L., & Smith, B.J. (2012). Mango modulates blood glucose similar to rosiglitazone without compromising bone parameters in mice fed high fat diet. J Pharm and Nutrition Sciences, 2(2): 115-126.
  • Rendina, E., Lim YF, Marlow D, Wang Y, Clarke, S.L., Kuvibidila, S., Lucas, E.A., & Smith, B.J. (2012). Dietary supplementation with dried plum prevents ovariectomy-induced bone loss in C57BL/6 mice and modulates the immune response. Journal of Nutrition, 23(1):60-8.
  • Shen CL, Smith, B.J., Lo DF, Chyu MC, Dunn DM, Chen CH, & Kwun IS (2012). Dietary Polyphenols and Mechanisms of Osteoarthritis. Journal of Nutritional Biochemistry, 23(11):1367-77.
  • Takedachi M, Oohara H, Smith, B.J., Iyama M, Kobashi M, Maeda K, Long CL, Humphrey MB, Stoecker, B.J., Toyosawa S, Thompson LF, & Murakami S (2012). CD73-generated adenosine promotes osteoblast differentiation. J Cell Phys, 227: 2622-31.
  • Chandra Christopher L, Lucas, E.A., Clarke, S.L., Smith, B.J., & Kuvibidila, S. (2011). White button and shiitake mushrooms reduce the incidence and severity of collagen-induced arthritis in dilute brown non-agouti mice. Journal of Nutrition, 141(1):131-136.
  • Christopher LC, Marlow D, Doffay J, Clarke, S.L., Smith, B.J., & Kuvibidila, S. (2011). Differential effects of shiitake- and white button mushroom-supplemented diets on hepatic steatosis in C57/BL6 mice. Food Chem Toxicol, 49(12):3074-80. PMID: 21925564
  • Davis MR, Shawron KM, Rendina E, Lucas, E.A., Smith, B.J., & Clarke, S.L. (2011). Hypoxia Inducible Factor 2-alpha is Translationally Repressed in Response to a Dietary Iron Deficiency in Sprague-Dawley Rats. Journal of Nutrition, 141(9): Epub 2011 Jul 13. PMID: 21753061
  • Lucas, E.A., Li W, Peterson SK, Brown A, Kuvibidila S, Perkins-Veazie P, Clarke, S.L., & Smith, B.J. (2011). Mango modulates body fat and plasma glucose and lipids in mice fed high fat diet. British Journal of Nutrition, 106(10):1495-505.
  • Lucas, E.A., Mahajan SS, Soung DY, Lightfoot SA, Smith, B.J., & Arjmandi BH (2011). Flaxseed but not flaxseed oil prevented the rise in serum cholesterol due to ovariectomy in the golden Syrian hamsters. J Med Food, 14(3):261-7.
  • Lukas R, Gigliotti JC, Smith, B.J., Altman S, & Tou JC (2011). Consumption of Different Sources of Omega-3 Polyunsaturated Fatty Acids by Growing Female Rats Affects Long Bone Mass and Microarchitecture. Bone, 49(3):455-62.
  • Peterson SK, Lucas, E.A., Traore D, Christopher LC, French C, Clarke, S.L., Lightfoot SA, Smith, B.J., & Kuvibidila, S. (2011). Effects of Portabella mushrooms on collagen-induced arthritis, inflammatory cytokines, and body composition in dilute brown non-agouti (DBA1) mice. Functional Foods in Health and Disease, 1(9):279-296.
  • Smith, B.J., Butler, A. A., Gimble, J. M., Sutton, G. M., Wu, X., Yu, G., Goh, B.C. , Hebert, T., Pelled, G., Gazit, Z., & Gazit, D. (2011). Ovariectomy and genes encoding core circadian regulatory proteins in murine bone. Osteoporosis International, 22(5), 1633-1639.
  • Halloran BP, Wronski T, VonHerzen D, Chu V, & Smith, B.J. (2010). Dietary Dried Plum Increases Bone Mass in Adult and Aged Mice. Journal of Nutrition, 140(10):1781-7.
  • Lucas EA, SK Peterson, SL Clarke, & Smith, B.J. (2010). Cardiovascular health benefits of grape Juice. Handbook of Oklahoma Vineyard Establishment and Management. Edited by ET Stafne. Oklahoma Cooperative Extension Service Circular E-1015, Invited Book Chapters
  • Lucas, E.A., Dumancas GG, Smith, B.J., Clarke, S.L., & Arjmandi BH (2009). Health benefits of bitter melon (Momordica charantia). Johnson CD, Lucas, E.A., Hooshmand S, Campbell S, Akhter MP, Arjmandi BH. Addition of fructooligosaccharides and dried pum to soy-based diets reverses bone loss in the ovariectomized rat. Evid Based Complement Alternat Med. 2008 Jul 30.
  • Bu, S.Y., Hunt, T.S., & Smith, B.J. (2009). Dried plum polyphenols attenuate the detrimental effects of TNF-:1 on osteoblast function coincident with up-regulation of Runx2, Osterix and IGF-I. Journal of Nutritional Biochemistry, 20(1):35-44.
  • Lawrance, C.C., Lucas, E.A., Clarke, S.L., Smith, B.J., & Kuvibidila (2009). Differential effects of isofluorane and CO2 inhalation on plasma levels of inflammatory markers associated with collagen-induced arthritis in DBA mice. Int. J. Immunopharmacol, 9(7-8):807-9.
  • Smith, B.J. (2009). Dried Plum Improves Bone Density and Microarchitecture by Up—regulating Osteoblast Activity and Down-regulating Osteoclast Differentiation. Acta Horticulturae, 841:441-447.
  • Smith, B.J., Lightfoot SA, Lerner MR, Denson KD, Morgan DL, Hanas JS, Bronze MS, Postier RG, & Brackett DJ (2009). Induction of cardiovascular pathology in an in vivo model of low-grade chronic inflammation. Journal of Cardiovascular Pathology, 18(1):1-10.
  • Bu, S.Y., Lerner, M., Stoecker, B.J., Boldrin, E., Brackett, D.J., Lucas, E.A., & Smith, B.J. (2008). Dried plum polyphenols inhibit osteoclastogenesis by downregulating NFATcl and inflammatory mediators. Calcified Tissue International, 82(6):475-88.
  • Hanas JS, Hocker JR, Cheung JY, Larabee JL, Lerner MR, Lightfoot SA, Morgan DL, Denson KD, Prejeant KC, Gusev Y, Smith, B.J., Hanas RJ, Postier RG, & Brackett DJ (2008). Biomarker Identification in Human Pancreatic Cancer Sera. Pancreas, 36(1):61-9.
  • Tripathi, Y.B., Tripathi, P., Korlagunta, K., Chai, S.C., Smith, B.J., & Arjmandi, B.H. (2008). Role of Sandhika: a polyherbal formulation on MC3T3-El osteoblast-like cells. Inflammation. Journal of Inflammation, 3l(l):l-8.
  • Bu SY, Lucas, E.A., Franklin M, Marlow D, Brackett DJ, Boldrin EA, Devareddy L, Arjmandi BH, & Smith, B.J. (2007). Comparison of dried plum supplementation and intermittent PTH in restoring bone in osteopenic orchidectomized rats. Osteoporosis International, 18(7):931-42.
  • Bu, S.Y., Lucas, E.A., Franklin, M., Marlow, D., Brackett, D.J., Boldrin, E.A., Devareddy, L., Arjmandi, B.H., & Smith, B.J. (2007). Restoration of bone mass and microarchitecture by dietary dried plum is comparable to PTH in osteopenic orchidectomized rats. Osteoporosis International, 18(7):931-42.
  • Denson, K.D., Morgan, D., Cunningham, R., Nigliazzo, A., Brackett, D.J., Lane, M., Smith, B.J., & Albrecht, R. (2007). Incidence of venous thromboembolism in patients with traumatic brain injury. Am Journal of Surgery, 193:380-383.
  • Droke EA, Hager KA, Lerner MR, Lightfoot SA, Stoecker, B.J., Brackett DJ, & Smith, B.J. (2007). Soy Isoflavones Avert Chronic Inflammation-induced Bone Loss and Vascular Disease. Journal of Inflammation, 4(17).
  • Droke, E.A., Hager, K.A., Lerner, M.R., Lightfoot, S.A., Stoecker, B.J., Brackett, D.J., & Smith, B.J. (2007). Soy isoflavones avert chronic inflammation—induced bone loss and vascular disease. Journal of Inflammation, (Lond) 4:l7-28.
  • Devareddy L, Khalil DA, Smith, B.J., Lucas, E.A., Soung DY, Marlow DD, & Arjmandi BH (2006). Soy moderately improves microstructural properties without affecting bone mass in an ovariectomized rat model of osteoporosis. Bone, 38(5):686-93.
  • Devareddy, L., Soung, D.Y., Smith, B.J., Lucas, E.A., Khalil, D.A., Marlow, D.D., & Arjmandi, B.H. (2006). Soy moderately improves bone mass and microstructural properties in an ovariectomized rat model of osteoporosis Bone, 38(5):686-93.
  • Franklin, M., Bu, S.Y., Lerner, M.R., Lancaster, E.A., Bellmer, D., Marlow, D., Arjmandi, B.H., Brackett, D.J., Lucas, E.A., & Smith, B.J. (2006). Dried plum down-regulates RANKL and OPG and prevents bone loss in a male model of osteoporosis. Bone, 39(6):1331-42.
  • Smith, B.J., Lerner, M.R., Bu, S.Y., Lucas, E.A., Hanas, J.S., Lightfoo, S.A., Bronze, M.S., Postier, R.G., & Brackett, D.J. (2006). Systemic bone loss and induction of coronary vessel disease in a rat model of chronic inflammation. Bone, 38(3):378-86.
  • Arjmandi, B.H., Lucas, E.A., Smith, B.J., Khalil, D.A., McDonald, J., Devareddy, L., Arquitt, A.B., Payton, M.E., & Mason, C. (2005). One year soy protein supplementation has positive effects on bone formation markers but not bone density in postmenopausal women, Nutrition Journal, 4(1): 8.
  • Boros, L.G., Lerner, M.R., Morgan, D., Taylor, S., Smith, B.J., Postier, R.G., & Brackett, D.J. (2005). Differential positional accumulation of [1,2-13] glucose into RNA ribose of DMBA-induced pancreatic tumors, pancreas, and liver. Pancreas, 31(4):337-343.
  • Deyhim, F., Smith, B.J., Juma, S., Soungh, D.Y., & Arjmandi, B.H. (2005). Ipriflavone modulates IGF-I but is unable to restore bone in rats. Phytochemistry Research, 19(2):116-20.
  • Khalil, D.A., Lucas, E.A., Smith, B.J., Soung, D.Y., Devareddy, L., Juma, S., Akhter, M.P., Recker, R., & Arjmandi, B.H. (2005). Soy isoflavones ameliorate bone loss in aged orchidectomized male rats. Calcified Tissue International, 76(1):56-62.
  • Smith, B.J., Lucas, E.A., Turner, R.T., Evans, G.L., Lerner, M.R., Brackett, B.J., Stoecker, B.J., & Arjmandi, B.H. (2005). Vitamin E provides protection for bone in mature hind limb unloaded male rats. Calcified Tissue International, 76(4):272-279
  • Arjmandi, B.H., Khalil, D.A., Lucas, E.A., Smith, B.J., Sinichi, N., Hodges, S.B., Juma, S., Munson, M.E., Payton, M.E., Tivis, R.D., & Svanborg, A. (2004). Soy protein may alleviate osteoarthritis symptoms, Phytomedicine, 11(7-8): 567-75.
  • Lucas, E.A., Hammond, L.J., Mocanu, V., Arquitt, A.B., Trolinger, A., Khalil, D.A., Smith, B.J., Soung, D.Y., Daggy, B.P., & Arjmandi, B.H. (2004). Daily consumption of dried plum by postmenopausal women does not cause undesirable changes in bowel function, Journal of Applied Research, 4: 37-43.
  • Lucas, E.A., Lightfoot, S.A., Hammond, L.J., Devareddy, L., Khalil, D.A., Daggy, B.P., Smith, B.J., Westcott, N., Mocanu, V., & Arjmandi, B.H. (2004). Flaxseed reduces plasma cholesterol and atherosclerotic lesion formation in ovariectomized Golden Syrian hamsters. Atherosclerosis, 173, 223-229.
  • Soung, D.Y., Khalil, D.A., Arquitt, A.B., Smith, B.J., Hammond, L.J., Droke, E.A., Lucas, E.A., Devareddy, L., & Arjmandi, B.H. (2004). Soy isoflavones prevent the ovarian hormone deficiency-associated rise in leukocytes in rats. Phytomedicine, 11, 303-308.
  • Arjmandi, B.H., Khalil, D.A., Smith, B.J., Lucas, E., Juma, S., Payton, M.E., & Wild, R.D. (2003). Soy protein has a greater effect on bone in postmenopausal women not on hormone replacement therapy as evidenced by reducing bone resportion and urinary calcium excretion. Journal of Clinical Endocrinology and Metabolism, 88(3), 1048-1054.
  • Brackett, D.J., Smith, B.J., Lerner, M.R., Hanas, J., & Postier, R.G. (2003). Gene activity associated with cancers treated by surgical oncologists. Okla State Med J., 96(10), 485-494.
  • Smith, B.J., Hermann, J., & Brown, B. (2003). Impact of a physical activity program emphasizing cardiovascular fitness, muscle strength and flexibility among middle-aged women. Journal of Nutrition Education and Behavior, 35(4), 215-216.
  • Arjmandi BH & Smith, B.J.   (2002). Skeletal Effectsof Phytoestrogens: Rodent Models; Diet in Phytoestrogens and Health AOCS Press, Champaign, IL , pp 354-370
  • Arjmandi, B.H. & Smith, B.J.   (2002). Soy isoflavones' osteoprotective role in postmenopausal women: Mechanism of action. Journal of Nutritional Biochemistry, 13(3), 130-137.
  • Arjmandi, B.H. & Smith, B.J.   (2002). Skeletal effects of phytoestrogens: Roden models; Diet. In: Gilani GS, Anderson JB, eds. Phytoestrogens and Health, AOCS Press, Champaign, IL., pp. 354-370.
  • Khalil, D.A., Lucas, E.A., Smith, B.J., Payton, M.E., & Arjmandi, B.H. (2002). Soy protein supplementation increases serum insulin-like growth factor-I in young and old men but does not affect markers of bone metabolism. Journal of Nutrition, 132(9), 2605-2608.
  • Smith, B.J., King, J.B., Lucas, E.A., Akhter, M., Arjmandi, B.H., & Stoecker, B.J. (2002). Skeletal unloading and dietary copper depletion are detrimental to bone quality of mature rats. Journal of Nutrition, 132(2), 190-196.
  • Arjmandi BH, Lucas, E.A., Juma S, Soliman A, Stoecker, B.J., Khalil DA, Smith, B.J., & Wang C (2001). Prune pevents ovariectomy-induced bone loss in rats. Journal of American Nutraceutical Association, 4(1):50-56.
  • Arjmandi, B.H., Lucas, E.A., Juma, S., Soliman, A., Stoecker, B.J., Khalil, D.A., Smith, B.J., & Wang, C. (2001). Dried plums prevent ovariectomy-induced bone loss in rats. Journal of the American Nutraceutical Association, 4(1), 50-56.