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Oklahoma State University

Dingbo (Daniel) Lin


Assistant Professor

419 Human Sciences
Stillwater, OK 74078
Phone: (405)744-5215
Fax: (405)744-1357


Degree Institution Area of Study
Ph.D. Zhejiang University, Hangzhou, China Biochemistry
M.S. Shanxi Agricultural University, Taigu, China Plant Physiology and Biochemistry
B.S. Zhejiang A & F University, Linan, China Forestry


Food bioactive compounds, Chronic inflammation, Insulin resistance, Hepatic steatosis, Obesity, Type 2 diabetes


  • Jiang,Y., Ma,H., Su,X., Chen,J., Standard,J., Lin, D., & Wang,W. (2012). IGF-1 mediates exercise-induced phospholipid alteration in the murine skin tissues. J Nutr Food Sci, S2
  • Getz,J., Lin, D., & Medeiros,D.M. (2011). The cardiac copper chaperone proteins Sco1 and CCS are up-regulated, but Cox 1 and Cox4 are down-regulated, by copper deficiency. Biol Trace Elem Res, 143(1):368-3777
  • Jiang,Y., Zhang,Y., Wark,L., Ortiz,E., Lim,S., He, H., Wang,W., Medeiros,D.M., & Lin, D. (2011). Wolfberry water soluble phytochemicals down-regulate ER stress biomarkers and modulate multiple signaling pathways leading to inhibition of proliferation and induction of apoptosis in Jurkat cells. J Nutr Food Sci, 2011 Nov 24;S2. Pii:001
  • Tang,L., Zhang,Y., Jiang,Y., Willard,L., Ortiz,E., Wark, L., Medeiros,D.M., & Lin, D. (2011). Dietary wolfberry ameliorates retinal structure abnormalities in db/db mice at the early stage of diabetes. Exp Biol Med, 236:1051-1063
  • Ayella,A, Lim,S., Jiang,Y., Iwamoto,T, Lin, D., Tomich,J., & Wang,W (2010). Cytostatic inhibition of cancer cell growth by lignin secoisolariciresinol diglucoside. Nutr Res., 30:762-769
  • Medeiros,D.M., Jiang,Y., Klaahsen,D.J., & Lin, D. (2009). Mitochondrial and sarcoplasmic protein changes in hearts from copper deficient rats: Upregulation of PGC1-α transcript and protein as a cause for mitochondrial biogenesis in copper deficiency. The Journal of Nutritional Biochemistry, 20:823-830
  • Yevseyenkov,V.V., Das,S., Lin, D., Willard,L., Davidson,H., Sitaramayya,A., Giblin,F., Dang,L., & Takemoto, D.J. (2009). Loss of protein kinase Cgamma in knockout mice and increased retinal sensitivity to hyperbaric oxygen. Arch Ophthalmol, 127:500-506
  • Zhang,Y., Snider,A., Willard,L., Takemoto,D.J., & Lin, D. (2009). Loss of Purkinje cells in the PKCgamma H101Y transgenic mouse. Biochem Biophy Res Comm. , 378:524-528
  • Barnett,M., Lin, D., Akoyev,V., Willard,L., & Takemoto,D.J. (2008). Protein kinase C epsilon activates lens mitochondrial cytochrome C oxidase Subunit IV during hypoxia. Exp Eye Res. , 86:226-234
  • Das,S., Lin, D., Jena,S., Shi,A., Battina,S., Hua,D., Allbuagh,R., & Takemoto, D.J. (2008). Protection of retinal cells from ischemia by a novel gap junction inhibitor. Biochem Biophy Res Comm. , 373: 504-508
  • Lin, D., Zampighi,G., & Takemoto, D.J. (2007). Protein kinase C gamma activation in the early streptozotocin-diabetic rat lens. Current Eye Res., 32:523-532
  • Lin, D. , Shanks,D., Prakash, O., & Takemoto,D.J. (2007). Protein kinase C gamma mutations in the C1B domain cause caspase-3-linked apoptosis in lens epithelial cells through gap junctions. Exp Eye Res. , 85:113-122
  • Lin, D. & Takemoto,D.J.   (2007). Protection from ataxia-linked apoptosis by gap junction inhibitors. Biochem Biophy Res Comm. , 362:982-987
  • Lin, D., Barnett,M., Lobell,S., Madgwick,D., Zampighi,G.A., & Takemoto, D.J. (2006). PKCgamma knockout mouse lenses are more susceptible to oxidative stress damage. J Exp Biol. , 209:4371-4378
  • Lin, D., Barnett,M., Robben,J., Jewell,A., Takemoto,L., & Takemoto, D.J (2005). Expression of SOD in whole lens prevents cataract formation. Mol Vis., 11:853-858
  • Lin, D. & Takemoto,D.J.   (2005). Oxidative activation of protein kinase C gamma through the C1 domain: effects on gap junctions. J Biol Chem., 280:13682-13693
  • Zampighi,G.A., Planells,A.M., Lin, D., & Takemoto,D.J. (2005). Regulation of lens cell-to-cell communication by activation of PKCgamma and disassembly of Cx50 channels. Invest Ophthalmol Vis Sci. , 46:3247-3255
  • Lin, D., Lobell,S., Jewell,A., & Takemoto,D.J. (2004). Differential phosphorylation of Cx46 and Cx50 by H2O2 activation of protein kinase C gamma. Mol Vis. , 10:688-695
  • Lin, D., Zhou,J., Zelenka,P., & Takemoto,D.J. (2003). Protein kinase C gamma regulation of gap junction activity through caveolin-1 containing lipid rafts. Invest Ophthalmol Vis Sci. , 44: 5259-5268
  • Lin, D., Boyle,D.J., & Takemoto,D.J. (2003). IGF-1-induced phosphorylation of connexin 43 by PKCgamma: Regulation of gap junctions in rabbit lens epithelial cells. Invest Ophthalmol Vis Sci. , 44:1160-1168

Courses Taught:

Principles of Human Nutrition, Spring 2014, team teaching NSCI  2114
Micronutrients in Nutrition, Spring 2014, team teaching NSCI  5043
Experimental Methods in Nutritional Sciences NSCI  5743


Awards & Recognition:

  • Travel Award, the International Conference of Food Science and Technology Innovation –FoodInnova-2012, China, 2012
  • National Eye Institute Travel Award to ARVO, NEI/NIH, 2007
  • Travel Fellowship Award, the American Neurological Association, 2006
  • Young Investigator Travel Award, the National Ataxia Foundation, 2005, 2008
  • STA Fellowship, Japan, 1998


  • Lin, D. (PI), Yao, W. (Co-PI). Egg lutein and inflammation.(Nov 2013-Oct 2014). American Egg Nutrition Center. ($112,000).
  • Lin, D. (PI). Dietary supplements protect retinal pigment epithelial cells from apoptosis.(Jul 2008-Jun 2013), NIH P20. ($330,000).
  • Lin, D. (PI). Wolfberry phytochemicals in prevention of leukemia. (Jan 2010- Dec 2010). Kansas State University Johnson Cancer Center Innovative Research Award. ($20,000).
  • Lin, D. (PI). The role of gap junctions in oxidative neurodegeneration in cerebellum.(Sep 2007-April 2009), NIH K-INBRE. ($75,000).
  • Lin, D. (PI). Mutations of protein kinase C gamma in spinocerebellar ataxia cause altered cell gap junctional communication. (Oct 2004-Oct 2006), National Organization for Rare Disorders (NORD). ($40,000).

Professional Memberships:

  • American Society for Nutrition
  • American Association for the Advancement of Science
  • Association for Research in Vision and Ophthalmology
  • American Society for Cell Biology
  • Society for Neuroscience


  • Reviewer:Journal of Nutrition, Molecular Nutrition and Food Research, PLOS ONE, Journal of Cell Science , Food and Function, Journal of Proteome Research, American Journal of Alzheimer’s Disease & Other Dementias
  • Editorial Board, Journal of Human Nutrition and Food Science
  • Editorial Board, Current Research in Nutrition and Food Science