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Oklahoma State University

McKale Montgomery

McKale Montgomery

Assistant Professor

416 Human Sciences
Stillwater, OK 74078
Phone: (405)744-4437
Fax: (405)744-1357

mckale.montgomery@okstate.edu

Education

Degree Institution Area of Study
Post Doc. Training Midwestern University Biomedical Sciences
Ph.D. Oklahoma State University Nutritional Sciences
M.S. Oklahoma State University Nutritional Sciences
B.S. Texas Christian University  Nutrition and Dietetics

Expertise

The goal of my research is to understand how molecular signals (like gene mutations) and environmental cues (like diet) contribute to cancer development.

Publications

Peer-reviewed publications

Hull EE, Montgomery MR, Leyva KJ:  Epigenetic Regulation of the Biosynthesis & Enzymatic Modification of Heparan Sulfate Proteoglycans: Implications for Tumorigenesis and Cancer Biomarkers.  International Journal of Molecular Sciences. 2017 Jun 26; 18(7). Pii: E1361

Belden SE, Uppalapati CK, Pascual AS, Montgomery MR, Leyva KJ, Hull EE, and Averitte RJ:  Establishment of a Clinic-Based Biorepository.  Journal of Visual Experimentation 2017 May 29;(123)

Hull E., Montgomery MR, and Leyva KJ: HDAC Inhibitors as Epigenetic Regulators of the Immune System: Impacts on Cancer Therapy and Inflammatory Diseases. BioMed Research International 2016;2016:8797206

Davis MR, Daggett JJ, Lam JM, Pascual AS, Cooper KE, Leyva KJ, Hull EE:  Characterization of the SW13 adrenal adenocarcinoma cell line and induction of subtype switching by HDAC1 inhibition.  BMC Cancer (2016): 16:316

Rendina-Ruedy E, Graef JM, Hembree KK, Davis MR, Lucas EA, Clarke SL, Gimble JM, and Smith BJ:  Strain Differences in the Attenuation of Bone Accrual in a Young Growing Mouse Model of Insulin Resistance.  Journal of Bone and Mineral Metabolism (2015): 1-15.

Rendina-Ruedy E, Hembree KK, Sasaki A, Davis MR, Lightfoot SA, Clarke SL, Lucas EA, and Smith BJ: A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 Diabetes. Journal of Nutrition and Metabolism (2015): 1-13.

Davis, MR, and Clarke, SL:  Influence of microRNA on the maintenance of human iron metabolism.  Nutrients 5.7 (2013): 2611-2628.

Rendina E, Hembree KK, Davis MR, Marlow D, Clarke SL, Halloran BP, Lucas EA, and Smith BJ:  Dried plum's unique capacity to reverse bone loss and alter bone metabolism in a postmenopausal osteoporosis. PloS one 8.3 (2013): e60569.

Davis MR, Hester KH, Shawron KM, Lucas EA, Smith BJ, and Clarke SL:  Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet. Nutrition & Metabolism9.1(2012): 1-10.

Davis MR, Rendina E, Peterson SK, Lucas EA, Smith BJ, and Clarke SL: Enhanced expression of lipogenic genes may contribute to hyperglycemia and alterations in plasma lipids in response to dietary iron deficiency. Genes & Nutrition 7.3(2012): 415-425.

Davis MR, Shawron KM, Rendina E, Peterson SK, Lucas EA, Smith BJ, and Clarke SL: Hypoxia inducible factor-2 alpha is translationally repressed in response to dietary iron deficiency in Sprague-Dawley rats. The Journal of Nutrition 141.9 (2011): 1590-1596.

Invited Book Chapters

Clarke SL, Davis MR, and Sunkar R:  Biogenesis of Mammalian microRNA. MicroRNAs as tools in Biopharmaceutical production.  Niall Barron, ed. (Springer, 2012).

Presentations

Presentations at national meetings

Montgomery MR and Hull EE:  HDAC inhibition and gain-of-function P53 mutation dictates oncogenic phenotype and influences iron metabolism in the SW13 cell line.  BioIron, Los Angeles, CA, May 7-11, 2017

Pulford CS, Loomis EM, Montgomery MR, Uppalapati CK, Pascual AS, Hull EE, and Leyva KJ (2017). MicroRNA Profile of Excised Cutaneous Squamous Cell Carcinoma Tissues Comparative to Adjacent Normal Tissue. Experimental Biology, Washington DC, April 22-16, 2017

Montgomery MR and Hull EE:  HDAC inhibitor treatment induces a metastatic phenotype in cell lines with p53 gain of function mutations.  American Society for Cell Biology, San Francisco, CA, Dec 3-7, 2017

Davis MR and Hull EE:  Heparan sulfate proteoglycans mediate SW13 oncogenic potential and response to granulin.  American Association for Cancer Research, New Orleans, LA, April 16-20, 2016

Davis MR, Gerona T, Leyva KJ, and Hull EE:  Microarray analysis reveals clues into the molecular signals controlling switching between metastatic and proliferative subtypes in the SW13 adrenal adenocarcinoma cell line.  American Society for Cell Biology, San Diego, CA, Dec 12-16, 2015

Gerona T, Davis MR, Hull EE:  miR-199a in Epigenetically Distinct Subtypes of the SW13 Human Adrenocortical Carcinoma Cell Line.  American Society for Cell Biology, San Diego, CA, Dec 12-16, 2015

Davis MR and Hull EE: Epigenetic mechanisms control switching between metastatic and proliferative subtypes in the SW13 adrenal adenocarcinoma cell line.  American Association for Cancer Research, Philadelphia, PA, April 18-22, 2015

Davis MR, Daggett JJ, Pascual AS, Cooper KE, Leyva KJ, Hull EE:  Characterization of the SW13 adrenal adenocarcinoma cell line and induction of subtype switching by HDAC1 inhibition. American Society for Cell Biology, Philadelphia, PA, Dec 6-10, 2014

Davis MR, Hester KK, Shawron KM, Lucas EA, Smith BJ, Clarke, SL:  Comparisons of the iron deficient metabolic response in rats fed either an AIN-76 or AIN-93 based diet. 

Trace Elements in Biology & Medicine, Steamboat Springs, CO, June 10-15, 2012

Davis MR, Rendina E, Lucas EA, Smith BJ, and Clarke SL:  Coordination of iron and oxygen sensing through post-transcriptional regulation of HIF-2α.  Experimental Biology, Washington DC, April 10, 2011

Shawron KM, Davis MR, Rendina E, Hester KK, Wang Y, Lucas EA, Smith BJ, and Clarke SL:  Dietary iron deficiency negatively alters bone microarchitecture in male Sprague-dawley rats.  American Society of Bone and Mineral Research, Toronto CA, October 18, 2010

Awards & Recognition

  • 2009 - 2013 OSU Foundation Distinguished Graduate Fellowship
  • 2009 - 2010 Gordon Carlson Endowed Graduate Scholarship, College of Human Sciences
  • 2009 - 2010 Catlett-Hageman Graduate Scholarship, College of Human Sciences
  • 2009 American Dietetic Association General Scholarship
  • 2007 Department of Nutritional Sciences Senior Scholar
  • 2007 First Team, ESPN The Magazine, Academic All-District VI selection
  • 2006 - 2007 USAA Collegiate All American Scholar
  • 2005 - 2007 Mountain West Conference Scholar Athlete
  • 2003 - 2005 Conference USA Commissioners’ Academic Honor Roll

Professional Memeberships 

  • Sigma Xi
  • American Society for Cell Biology
  • American Association for Cancer Research
  • Women in Cancer Research